Ethyl acetate

Ethyl ethanoate
Names
	Preferred IUPAC name Ethyl acetate
	Systematic IUPAC name Ethyl ethanoate
	Other names Acetic ester; Acetic ether; Ethyl ester of acetic acid; Ethanoic ethyl ester;
Identifiers
CAS Number	141-78-6 ;
3D model (JSmol)	Interactive image;
Beilstein Reference	506104
ChEBI	CHEBI:27750 ;
ChEMBL	ChEMBL14152 ;
ChemSpider	8525 ;
ECHA InfoCard	100.005.001
E number	E1504 (additional chemicals)
Gmelin Reference	26306
KEGG	D02319 ;
PubChem CID	8857;
RTECS number	AH5425000;
UNII	76845O8NMZ ;
CompTox Dashboard (EPA)	DTXSID1022001 ;
	InChI InChI=1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3 Key: XEKOWRVHYACXOJ-UHFFFAOYSA-N ; InChI=1/C3H8O2/c1-3-6-4(2)5/h3H2,1-2H3 Key: XEKOWRVHYACXOJ-UHFFFAOYAD;
	SMILES O=C(OCC)C;
Properties
Chemical formula	C4H8O2
Molar mass	88.106 g·mol−1
Appearance	Colorless liquid
Odor	nail polish-like, fruity
Density	0.902 g/cm3
Melting point	−83.6 °C (−118.5 °F; 189.6 K)
Boiling point	77.1 °C (170.8 °F; 350.2 K)
Solubility in water	8.3 g/100 mL (at 20 °C)
Solubility in ethanol, acetone, diethyl ether, benzene	Miscible
log P	0.71
Vapor pressure	73 mmHg (9.7 kPa) at 20 °C
Acidity (pKa)	25
Magnetic susceptibility (χ)	−54.10×10−6 cm3/mol
Refractive index (nD)	1.3720
Viscosity	426 μPa·s (0.426 cP) at 25 °C
Structure
Dipole moment	1.78 D
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Flammable (F),; Irritant (Xi);
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H225, H319, H336
Precautionary statements	P210, P233, P240, P305+P351+P338, P403+P235
NFPA 704 (fire diamond)	2 3 0
Flash point	−4 °C (25 °F; 269 K)
Explosive limits	2.0–11.5%
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	11.3 g/kg, rat
LC50 (median concentration)	16,000 ppm (rat, 6 h); 12,295 ppm (mouse, 2 h); 1600 ppm (rat, 8 h)
LCLo (lowest published)	21 ppm (guinea pig, 1 h); 12,330 ppm (mouse, 3 h)
	NIOSH (US health exposure limits):
PEL (Permissible)	TWA 400 ppm (1400 mg/m3)
REL (Recommended)	TWA 400 ppm (1400 mg/m3)
IDLH (Immediate danger)	2000 ppm
Related compounds
Related carboxylate esters	Methyl acetate,; Propyl acetate,; Butyl acetate;
Related compounds	Acetic acid,; Ethanol,; Diethyl ether;
Supplementary data page
	Ethyl acetate (data page)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Ethyl acetate commonly abbreviated EtOAc, ETAC or EA) is the organic compound with the formula CH₃CO₂CH₂CH₃, simplified to C₄H₈O₂. This flammable, colorless liquid has a characteristic sweet smell (similar to pear drops) and is used in glues, nail polish removers, and the decaffeination process of tea and coffee. Ethyl acetate is the ester of ethanol and acetic acid; it is manufactured on a large scale for use as a solvent.^[5]

^ "ethyl acetate MSDS".
^ ^a ^b ^c ^d ^e NIOSH Pocket Guide to Chemical Hazards. "#0260". National Institute for Occupational Safety and Health (NIOSH).
^ ^a ^b ^c Record of Ethyl acetate in the GESTIS Substance Database of the Institute for Occupational Safety and Health, accessed on 7 December 2020.
^ ^a ^b "Ethyl acetate". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
^ Riemenschneider, Wilhelm; Bolt, Hermann M. "Esters, Organic". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a09_565.pub2. ISBN 978-3-527-30673-2.

[chemsrc-1] "ethyl acetate MSDS".

[NIOSH-2] NIOSH Pocket Guide to Chemical Hazards. "#0260". National Institute for Occupational Safety and Health (NIOSH).

[GESTIS-3] Record of Ethyl acetate in the GESTIS Substance Database of the Institute for Occupational Safety and Health, accessed on 7 December 2020.

[IDLH-4] "Ethyl acetate". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).

[Ullmann-5] Riemenschneider, Wilhelm; Bolt, Hermann M. "Esters, Organic". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a09_565.pub2. ISBN 978-3-527-30673-2.

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